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The preclinical literature is extensive and spans more than three decades, with animal model data generally supporting a manageable safety profile at the concentrations and study durations examined

PMID: 11028671 Rahman I, MacNee W

The method according to any one of claims 59-72, wherein said immunoconjugate or antibody is administered in a pharmaceutical composition comprising a pharmaceutical acceptable carrier

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LNPs can typically be designed with a specific surface charge to either increase or reduce electrostatic interactions with mucins, such as through the incorporation of chitosan or cationic amphiphilic drugs 124,191

doi: 10.1128/mBio.00886-20 60