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Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment
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Freund TF, Katona I, Piomelli D (2003)

Melanocortin agonists include PT-141 and Melanotan II, while mitochondrial and longevity peptides include MOTS-C and Epithalon

This highlights the roles of inflammation, oxidative stress, and leptin and insulin resistance in disrupting the hypothalamic-pituitary-testicular axis in men with metabolic disease
