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The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

pylori -dependent gastric tumor, the long-term absence of CLDN 18 could initiate the formation of gastric tumors in a chronic gastritis mouse model without H

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The injection, made by GlaxoSmithKlein, has now been approved by the FDA for high-risk people