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The low energy barrier for the rotation of the catechol group in DA allows greater conformational sampling and enables it to interact in close proximity to the subsite B of the primary binding site

We also examined this dataset using the HumanBase tool and identified Wnt signaling as one of the major cartilage-specific modules

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Gene expression profiling identified several novel transcripts in human keratinocyte cells that were significantly up- and down-regulated including the selected targer genes (TGF-1, TIMP1 and COL1A1), and others (Fig