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In a mouse ischemiareperfusion injury model, castration attenuated the inflammatory response in male mice, whereas ovariectomy aggravated tubular injury and increased the expression of TNF- , MCP-1, IFN- , and CCL17 in female mice

1 which shows the relationships and interplay between microglial activation and the neuropathology, medical issues and symptoms in ASD)

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Animal models support tissue-specific changes, with decreased pancreatic Cu/Zn-SOD activity observed in CF porcine models (OMalley et al., 2022)

EDV significantly attenuated the loss of neurons in the hippocampus and medial prefrontal cortex (mPFC), microglial activation, oxidative stress damage, and astrocyte dysfunction via the Sirt1-Nfr2-HO-GPX4 pathway