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Drug structure optimization By optimizing the drugs structure, its efficacy can be enhanced, toxicity can be reduced, pharmacokinetic properties can be improved, and stability can be increased

Qi X, Ng KT, Shao Y, Li CX, Geng W, Ling CC, Ma YY, Liu XB, Liu H, Liu J, et al

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Under normal physiological conditions, lung tissue primarily acquires iron through the bloodstream, while iron inhaled directly via the respiratory tract accounts for only a minimal fraction

In this context, it is plausible to consider A1AT as a protective host factor against COVID-19, not only decreasing SARS-CoV-2 entry, but also protecting from the main clinical complications, such as acute inflammation and acute respiratory insufficiency (67)

Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells