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Nevertheless, the recently concluded Age-Related Eye Disease Study 2 (AREDS2) trial was unable to confidently demonstrate protective effects of L/Z [81,83], and whether L/Z may protect against early AMD also remains unknown

A: Filtration is a trade-off rather than a universal requirement, and the answer depends on what the research protocol is attempting to control for

Conversely, men have higher risk of inflammation or tissue damage due to higher amount of cytokines and chemokines like IL-2, TNF, IL-7, IL10, IL-18, CCL14, or CCL23 (144)

Funding This work was supported by the Juvenile Diabetes Research Foundation (grant #: 2-SRA2020-910-S-B to JP), UPMC Childrens Hospital of Pittsburgh Foundation Cochrane Weber Endowed Fund (awarded to JP), and a UPMC Childrens Hospital of Pittsburgh Research Advisory Committee (RAC) Predoctoral Fellowship (awarded to CM)

[30] [32] While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques

Wang, Q., Hardie, R.-A., Hoy, A
