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Abstract Trimethylamine N-oxide (TMAO), the oxidized form of trimethylamine (TMA), was previously thought to be a waste product but is now considered an important risk factor for cardiovascular disease (CVD) and its comorbidities

Valproate-phenobarbital interaction: [1] Valproate may reduce phenobarbital metabolism

The supplement may also interact with certain chemotherapy drugs, so cancer patients should always discuss supplementation with their oncologist before use

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H.et al (2021a)