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Determination of the in vitro metabolic stability of NMY1009 and FCCP upon incubation with rat liver microsomes NMY1009 and FCCP were detected by LCMS/MS using the Agilent 1290 Infinity HPLC system (Agilent Technology, Waldbronn, Germany) coupled to a Q Trap 5500 hybrid triple quadrupole linear ion trap mass spectrometer (Applied Biosystems/MDS Sciex, Concord, Ontario, Canada)

Very strong correlation was established between GCLc and GR (0.974, p =0.005) and GS (0.935, p =0.020) expression and between GS and GR (0.886, p =0.045) expression levels (Table

It is notable that even if the pathway is absent, ascorbate is present in some of these compartments, albeit in more oxidised form (Conklin et al

doi: 10.1007/s40520-019-01209-3, 56

& Delwiche, E

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