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Carbaglu ), a structural analog of N -acetylglutamate, is an effective and generally well-tolerated option for the treatment of hyperammonaemia due to propionic, methylmalonic and isovaleric acidurias

A can further perturb lipid homeostasis by its ability to bind metal ions, which can catalyze the generation of lipid peroxidation products using polyunsaturated fatty acids as electron donors ( In connection to these findings, GWAS have identified several genes encoding proteins involved in lipid homeostasis (Lambert et al., 2013)

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These observations led to growing interest in biomarkers that measure atherogenic particle number and inherited lipoprotein risk more directly