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*Correspondence: Xiaohong Li, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

People with homozygous MTHFR, have anomalies in both the genes, which means that the enzyme activity can drop by as much as ninety percent

The oxidative and carbonyl stress induced by MGO are mediated through multiple signaling pathways, including NF-B, MAPK, and Nrf2

Pathologe 39, 189192

T13 exhibited inhibitory activity of d-lactate formation and cytotoxicity in DMS273 cells at comparable concentration ranges (IC 50 = 4.6 M, LC 50 = 1.9 M, Fig