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Activation of PERK results in the increased expression of activating transcription factor 4, which is a major ER stressor [48]

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However, some of the recommendations have possibly resulted in more harm than good

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The investigators reported faster reepithelialization and reduced post-treatment erythema in the GHK-Cu arm compared with standard care, consistent with prior clinical trials of GHK-Cu in diabetic ulcers and Mohs surgical wounds [2]
