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Polmacoxib is an orally active dual inhibitor of COX-2 and carbonic anhydrase (CA)

1 Glutamine, Glutamate, and GABA: Metabolic Aspects
In higher eukaryotes GCL is a heterodimer comprising a catalytic (GCLC) and a modifier (GCLM) subunit 7

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In 1970, several investigators more thoroughly characterized the chemistry of peroxynitrite showing that it decomposed to form hydroxyl radical and nitrogen dioxide (85, 401, 580, 581, 832)
