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Their effect remains subject to somatostatin's inhibitory tone, keeping them within the natural feedback system

Activation of NF-kB/Rel proteins therefore requires degradation of IkB proteins via ubiquitin-mediated proteolysis to initiate nuclear translocation and DNA binding of active NF-kB/Rel complexes [84]

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Another reason is consistency

The detection time of a peptide depends not just on how long it remains active , but also on how long its metabolites or molecular fingerprints can be identified in blood, urine, or tissue samples

As chemotherapeutic drug currently in clinical use are cytotoxic drug, they all damage normal cells to varying degrees, and various toxic side effects (e.g