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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis

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Mitochondrial dysfunction leads to a reduction in ATP production and the accumulation of reactive oxygen species (ROS), which can cause tissue hypoxia and oxidative stress, thereby directly stabilizing the HIF-1 protein (inhibiting its ubiquitination and degradation) (34)