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Butyrate optimizes mitochondrial function, with effects that involve an increase in mitochondria-located sirtuins-3, which deacetylates and disinhibits the pyruvate dehydrogenase complex (PDC), leading to an increase in the conversion of pyruvate to acetyl-CoA, which increases ATP production by the tricarboxylic acid (TCA) cycle and oxidative phosphorylation [208]