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During puberty, a 3-fold increase in pulsatile GH secretion occurs that peaks around the age of 15 years (yr) in girls and 1 yr later in boys (9)

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Heterogeneities were evaluated both within and between study designs across America (I 2 = 0.0%, p = 0.592), Asia (I 2 = 96.2%, p = 0.000), Europe (I 2 = 63.6%, p = 0.017), and overall (I 2 = 83.6%, p = 0.000) (Fig

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Pfisterer K, Shaw LE, Symmank D, et al
