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Exposure to toxins such as cigarette smoke, air pollution, and heavy metals can also deplete glutathione levels. The Role of Glutathione in Alcohol Metabolism Glutathione plays a crucial role in the metabolism and detoxification of alcohol by helping eliminate acetaldehyde, a toxic byproduct

Taken together, C57BL/6J mice are more susceptible to oxidative hepatic injury compared with 129X1/SvJ mice after acute arsenic exposure, which is closely associated with arsenic methylation pattern of the two strains.