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Description
In this study, based on sparse somatic mutation data from 4581 NSCLC patients from the Memorial Sloan Kettering Cancer Center (MSKCC) database, we systematically evaluate the metabolic pathway activity in NSCLC patients through the application of network propagation algorithm and computational biology algorithms

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* Bio-GEE : biotinylated glutathione ethyl ester DTT : 1,4-dithiothreitol ETC : electron transport chain GSH : reduced glutathione GSSG : oxidized glutathione LDH : lactate dehydrogenase LPS : lipopolysaccharide MitoCDNB : Mitochondrially-targeted 1-chloro-2,4-dinitrobenzene NEM : N-ethylmaleimide OGDHC : 2-oxoglutarate dehydrogenase complex PDC : pyruvate dehydrogenase complex PDCE2 : PDC E2 component PDCE3 : PDC E3 component ROS : reactive oxygen species SDS-PAGE : sodium dodecyl sulfate-polyacrylamide gel electrophoresis TLR : toll-like receptor