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The PEXEL is located at a conserved position in exported proteins (1530 amino acids C-terminal to the signal sequence) 13 and we investigated the effect of shifting this position towards the N-terminal signal sequence

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trans -Platinum(II) complexes with one aliphatic amine ligand, such as trans -[PtCl 2 (NH 3 )L] where L = 2-methyl-butylamine or sec -butylamine, have been prepared with the aim of improving the water solubility of the parent di-aliphatic amine complexes