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GR is another critical enzyme involved in antioxidant defense and responsible for reducing GSSG back to its reduced form GSH, which is pivotal for the cellular antioxidant protection 53

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doi: 10.1177/15330338221114178 67 SmithTJ

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Despite these challenges, the ongoing research in this field holds promise for advancing therapeutic strategies that exploit the vulnerabilities of cancer cells dependent on glutamine for their survival and proliferation (Figure 3)