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We demonstrated that overcoming this limitation through exogenous supplementation of nitric oxide, a molecule whose production otherwise is reduced in high-grade PCa, can reinstate the S-nitrosylation of MYCN at specific sites (Cys4, Cys186, Cys46)

Garcia-Reitbock P, Anichtchik O, Bellucci A, Iovino M, Ballini C, Fineberg E, et al

doi: 10.1093/hmg/ddt585

doi: 10.1152/ajpgi.00503.2001

All these changes have been linked to the existence of a chronic detrimental low-grade inflammatory state in the adipose tissue (62)