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The mean values in the examined five microscopic fields were considered the final lesion score per animal
The metabolism of anticancer drugs by GSTs is a process that leads to loss of drug efficacy, as in the case of 1,3-di-(2-chloroethyl)-1-nitrosourea (BCNU), cyclophosphamide and melphalan (Figure 3eg) [40]
They were housed in polypropylene cages, five mice per cage, in a controlled environment maintained at 23 2 C with a 12-hour light/12-hour dark cycle, and allowed to acclimate for one week before experimentation
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Hermanson, T., Bennett, C
pK a determination of water-insoluble drugs in organic solvent-water mixtures
