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That is a large part of why B12 has such a favorable safety record

Nausea represents the most commonly reported side effect in clinical trials

A corresponding moderate increase in the functional metabolic biomarkers plasma methymalonic acid and homocysteine suggests that some depletion of maternal intracellular vitamin B12 has occurred even though serum B12 concentrations are high (Varsi et al., 2018)

It is the difference between knowing what you are putting in your body and hoping for the best
The first injection almost always causes nausea, which goes away after a few doses

Why is Vitamin B-12 So Important
