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However, it is insoluble in acetone, ether, and benzene

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A well-characterised pro-oxidant effect of ascorbate derives from its ability to reduce Fe 3+ and Cu 2+ , resulting in hydroxyl radical production in the Fenton reaction between Fe 2+ /Cu + and H 2 O 2 [9]

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This represents a measure of depth of invasion of the tumour into the dermis

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