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doi: 10.1007/s11302-021-09822-6

10.1016/j.amjms.2018.01.002 82 TaoF.QianC.GuoW.LuoQ.XuQ.SunY

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Lu khi dng: Hiu qu cn ph thuc vo c a tng ngi, liu trnh hiu qu t 45 60 ngy

These studies aim to understand how tesofensine measures up against existing treatment options, providing valuable data for healthcare providers and patients alike

For instance, hypoxia induces extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation to activate HIF-1, which directly binds to the promoter of ABCG2 gene and subsequently enhances ABCG2 transcription, leading to gemcitabine chemoresistance in pancreatic cancer cells (He et al., 2016)