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In this review, we summarize the recent advances in the regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy and explore the prospect of combining Nrf2 inhibitors and ferroptosis inducers as a promising cancer treatment strategy.

National Cancer Institute, CA231997, CA285740, CA245471, CA124435 Deutsche Forschungsgemeinschaft, CRC1399, CRC1403, CRC1310, CRC1530, SPP2306

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