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Ponten H, Kullingsjo J, Lagerkvist S, Martin P, Pettersson F, Sonesson C, et al

J Am College Cardiol
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Nrf2-ARE, nuclear factor erythroid 2-antioxidant responsive element
Nanoparticle-mediated drug delivery systems have emerged as a transformative approach to address these limitations by improving drug solubility, stability, and targeted delivery to infected cells and viral sanctuaries such as the brain, lymphoid organs, and gastrointestinal mucosa

In another rat study, brain infarction was significantly lower in animals which were treated intranasally with KND (a DSIP analog) at a dose of 300 mcg/kg, compared to controls [28]
