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It should also be emphasized that the role of the gut microbiota in ASD remains the subject of lively debate, and recent studies point to significant conceptual and methodological limitations, including issues related to causality, reproducibility of results, and confounding variables, which should also be kept in mind when interpreting the existing research findings, particularly with respect to causal inference and reproducibility [134]

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However, with the continual development of proteomics and proximity labeling technology, the limitations of this technology are increasingly prominent

Abstract Consistent evidence associates IGF-1 deficiency and metabolic syndrome