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Therefore, low cellular energy states will lead to induction of 2-oxoglutarate production via the glutamate dehydrogenase reaction allowing for increased ATP synthesis from the TCA cycle-derived NADH and FADH 2

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Vascular dark circles result from thin periorbital skin (thinnest on body at 0.5mm vs 2mm average facial skin) allowing visualization of underlying blood vessels and pooled deoxygenated blood appearing blue-purple through skin surface

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