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doi: 10.3390/medicina60111896 52 ShojaeiZJafarpourRMehdizadehSBayatipoorHPashangzadehSMotallebnezhadM

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Surprisingly, acute administration (1 h) still improves muscle fatigue resistance and improves muscle ATPmax and ADP sensitivity in vivo in aged mice [7, 14]

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The distinction is kinetic profile: IM produces higher plasma peaks within 3060 minutes but declines faster, while SubQ creates sustained elevation over 46 hours