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Peptide incompatibilities can result in degradation, reduced efficacy, or altered bioactivity

FOXO4 facilitates TM3 Leydig cell senescence and maintains the viability of senescent cells To further validate the role of FOXO4 in senescent Leydig cells, we silenced FoxO4 expression using siRNA prior to senescence induction

Many of these studies rely on the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-type 2 diabetes) repository or the consolidated PanKbase ( [43]

This review aims to fill these gaps by offering a comprehensive assessment of GSHs dual role in cancer biology, systematically examining nanotechnology-enabled approaches (such as disulfide and diselenide linkages, transition metal systems, and prodrugs), and critically evaluating their strengths, limitations, and potential for clinical translation