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they are rooted in measurable physiological dysfunctions, including severe oxidative stress, mitochondrial impairment, and systemic inflammation

Tang J, Zhou Q, Zhao F, Wei F, Bai J, Xie Y, Huang Y (2015) Association of glutathione S-transferase T1, M1 and P1 polymorphisms in the breast cancer risk: a meta-analysis in Asian population

GrafftCACornellLDGloorJMCosioFGGandhiMJDeanPGet alAntibody-mediated rejection following transplantation from an HLA-identical sibling

Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: a double-blind randomized controlled clinical trial

27 Inflammation Obesity associated with overnutrition induces macrophage infiltration and chronic hypoxia, causing low-grade inflammation in the adipose tissue 28 and the release of proinflammatory factors such as interleukin (IL)-1 and tumor necrosis factor (TNF-), 29,30 thus impairing insulin signaling pathway in a number of ways

Lane at the Mass Spectrometry & Proteomics Resource Core at Harvard University, and by Ulf Bergmann at Proteome Factory AG in Berlin, Germany