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None of the remaining authors had financial or other interests in connection to the study

As their name suggests, integral proteins (some specialized types are called integrins) integrate completely into the membrane structure, and their hydrophobic membrane-spanning regions interact with the hydrophobic region of the phospholipid bilayer (Figure 21)

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Figge, R

Examples fall into three categories: (1) in vivo models consisting of the administration of IEMs accumulating metabolites to mimic the defect in wild-type rats