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Supports immune function: Helps the body coordinate a healthy response to environmental challenges
ROS can also activate autophagy by phosphorylating JNK in human breast cancer cells (Sun et al., 2017)

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In non-alcoholic fatty liver disease (NAFLD), curcumin reduces the incidence and severity due to its lipid-lowering, insulin-sensitizing, antioxidant, and anti-inflammatory properties, selectively inhibits 11beta-HSD1 to modulate glucocorticoid levels, improves glycolipid metabolism, indirectly downregulates SLC13A5 and ACLY expression by activating the AMPK-raptor-mTOR signaling pathway, upregulates PPAR-alpha expression, inhibits SREBP-1, decreases serum fetuin-A expression, mitigates fat accumulation, modulates inflammation, enhances antioxidant defense, prevents fibrosis through inhibition of Nrf2/ARE and NF-B signaling pathways, reduces serum levels of inflammatory cytokines, triglyceride (TG), total cholesterol (TC), and free fatty acids (FFA), decreases malondialdehyde (MDA) presence, increases glutathione (GSH) and heme oxygenase-1 (HO-1) levels, regulates oxidative stress by enhancing SOD activity, and suppresses M1 macrophage activation to reduce pro-inflammatory cytokines IL-1beta and TNF-alpha