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There is no tolerance development meaning effectiveness persists over time, no rebound anxiety or insomnia upon discontinuation, and no dependency issues enabling sustainable long-term use when medically appropriate

Individual circumstances and goals should guide this decision

Current evidence suggests that simple fatty liver does not directly cause B12 deficiency, but the metabolic conditions, medications, and dietary patterns often associated with fatty liver can increase deficiency risk

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Salimetrics recommends using the 3k method to calculate DLMO (Voultsios et al., 1997, Molina and Burgess, 2011)

Pancreatitis, gallbladder concerns, kidney issues, and severe allergic reactions may all be possible, but are less of a concern