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The Affordable Care Act revised the Medicare DSH payment methodology and provides for an additional Medicare payment beginning on October 1, 2013, that considers the amount of uncompensated care furnished by the hospital relative to all other qualifying hospitals

Multiple mechanisms, namely, altered drug targets and bypass signaling pathways, enhanced drug efflux and metabolism, downstream adaptive responses, and maintenance of cancer stemness, are the primary causes of decreased anti-cancer drug effectiveness (4750)

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