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Among the M1-secreted cytokines, IL6 can induce lipid peroxidation and disrupt iron homeostasis in bronchial epithelial cells, ultimately resulting in ferroptotosis (74)

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The ryanodine receptor is involved in release of Ca 2+ from the SR so, although it is evident that SELENON loss results in impairment of Ca 2+ homeostasis, the origin of this defect remains unclear and may involve both the release (ryanodine receptor) and re-uptake (SERCA) of Ca 2+