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However, it would have been more accurate to have added an only wortmanin control in Figure 6

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This compound is a human Rho kinase inhibitor that has been approved for therapy in cerebral vasospasm and glaucoma [273] with the capacity to cross the BBB and exerts neuroprotection in MPTP-treated mice [274]

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Lurie when he was an Associate Commissioner at FDA, and previously cited by FDA Commissioner Makary, most CRLs (87 percent) issued between 2008 and 2013 cited important clinical deficiencies in safety, efficacy, or both

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