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Meldonium has been described as metabolized via 3-hydroxypropionic acid with formation of succinic acid ( Effects on oxidative stress and inflammation-linked mitochondrial dysfunction Hypoxia and intense exertion can promote inflammatory signaling and oxidative stress, contributing to mitochondrial dysfunction

Accordingly, when DJ1 is missing or mutated, AGE accumulation and a-syn aggregation ultimately cause DN death

doi: 10.1016/j.yrtph.2018.03.019 145

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