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Interestingly, metformin treatment affected similarly the metabolic profile of two unrelated breast cancer cell lines (MCF-7 and BT-474), with the strongest effect observed for MCF7 cells on the PC2

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When such studies were undertaken10 they revealed that the relative sensitivity of freshly isolated hepatocytes from mouse, rat and hamster reflected that in vivo and that human hepatocytes were relatively resistant to the cytotoxicity of APAP (Fig

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