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These results suggest a metabolic shift in ME/CFS patients from a hypometabolic state at baseline, characterized by down-regulated pathways to a hypermetabolic state post-exercise, characterized by over-activated pathways

[DOI] [PubMed] [Google Scholar] 101.Mitchell JR

These so-called reductive macrophages predominated and were associated with sustained maintenance of Th1 prevalence during aging until 2 years in the transgenic mice, while wild type littermates showed a rapid polarization to Th2 at 8 months

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doi: 10.1093/carcin/22.8.1289

They reported that patients with NAFLD had significantly higher serum homocysteine levels than healthy controls 24