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In micro- and macroautophagy, the cytoplasmic phagophores that engulf various cargos is delivered to the lysosome or by an autophagosome, respectively, while in chaperone-mediated autophagy, targeted proteins binding with chaperone proteins are translocated across the lysosomal membrane [148]

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Antioxidant enzyme systems regulated by Nrf2 include MnSOD, CAT, sulfaredoxin (Srx), thioredoxin, peroxiredoxin, GPx, GR, GCL, GCS, NADPH quinone oxidoreductase 1 (NQO1), and heme oxygenase 1 (HO-1) (83)