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Considerations Individual variability: DSIPs effects seem highly person-specific

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The peptide promotes angiogenesisthe formation of new blood vessels from existing vasculaturethrough activation of the VEGFR2-Akt-eNOS signaling pathway

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Relatively little of this impact is scientifically proven, but the potential downsides are minimal and the upsides are significant, so many people find it worth trying

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Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids

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Verify peptide purity through independent analysis impure or incorrectly sequenced compounds invalidate study results

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