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[20] Researchers sought to validate earlier laboratory studies relating to carnitines effects on improving thyroid hormone levels

Levocarnitine was not bound to plasma protein or albumin when tested at any concentration or with any species including the human.9 In a pharmacokinetic study where five normal adult male volunteers received an oral dose of [3H-methyl]-L-carnitine following 15 days of a high carnitine diet and additional carnitine supplement, 58 to 65% of the administered radioactive dose was recovered in the urine and feces in 5 to 11 days

Considering in vitro studies with Sertoli cells, pre-clinical studies, and investigations involving infertile men, a comprehensive understanding of the effects of L-Carnitine has been established