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a slight reduction in systolic blood pressure (-2.5 mm Hg) has been observed in hypertensive individuals

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The interplay among these modifications determines its transcriptional activity under metabolic stress

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Elevated plasma concentrations of TMAO have also been linked with a long-term mortality risk in patients suffering from heart failure, advanced left-ventricular diastolic dysfunction, and atherosclerotic development in patients suffering from atherosclerotic coronary artery disease (Tang et al., 2013

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