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Furthermore, increased levels of the metabolite Acetyl-coA directly promote cell-ECM adhesion by donating the necessary acetyl group for lysine acetylation in cross-linking ( Effects of GBM Proteases on Cellular Metabolism While adhering to the ECM allows GBM cells to migrate and disperse throughout the cerebral microenvironment efficiently, invasive tumors must also slice through the matrix to seed tumor cells in adjacent brain tissue

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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.David B, Bafadhel M, Koenderman L, et al
