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in: PubMed | Google Scholar | Published December 22, 2022 - More info Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth

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DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1

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Moreover, studies in wheat have shown that amino acid metabolism is activated as part of osmotic regulation under high-light stress conditions (Gyugos et al