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For glycemic control in type 2 diabetes, treatment is typically continued indefinitely as long as it remains effective and well-tolerated, with periodic assessment of the ongoing need for therapy

Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations

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When medication is combined with provider oversight, dietary guidance, and follow-through, patients are often better positioned to stay on track than they would be with willpower alone

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