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Remarkably, 5-cholesten-3-one, derived by oxidation of the 3-hydroxyl group of cholesterol, is not a substrate in spite of a structure of the A and B rings identical to that in 5-AD and 5-PD, in which the double bond isomerization occurs (Figure 2)

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Similarly, in laryngeal cancer, GPx1 upregulation was associated with lymph node metastasis and cancer stage and was an independent predictor of patient survival (HR, 2.101, 95%CI, 1.0114.367) [137]